Journal: Experimental & Molecular Medicine

Article Title: Progressive neuroinflammation and deficits in motor function in a mouse model with an Epg5 pathogenic variant of Vici syndrome

doi: 10.1038/s12276-026-01644-z

Figure Lengend Snippet: a , b Weight comparison of mutant homozygous mutant with sibling control WT mice at 4 weeks ( a ) and 8 weeks (wk) of age ( b ). c – e In comparison to control mice ( c ), W860X homozygous mutant mice ( d ) display poorly placed hindlimbs when attempting to bear weight at 4 months of age. Hindlimb function in homozygous W860X mice is progressively more severe by 7 months of age ( e ). f – i An assessment of motor function of W860X ( f and g ) and KO ( h and i ) mutant mice via rotarod. In comparison to age-matched control siblings, homozygous mutant mice have poor capacity to navigate rotarod test of coordination. Mutant mice fail the test at lower speed of rotation (‘speed at fall’; f and h ) and at shorter time (‘latency to fall’; g and i ) on the apparatus. At later ages starting at 12 weeks, some homozygous mutant animals are unable to initiate the rotarod test, and all W860X mice fail at 14 weeks and all KO mice fail at 16 weeks. Analysis of data between WT and mutant mice at a given time point was performed via an unpaired t -test. **** P < 0.0001, *** P < 0.001, ** P < 0.01 and * P < 0.05.

Article Snippet: The analysis of motor coordination, endurance and fatigue resistance was performed via the rotarod test (Panlab).

Techniques: Comparison, Mutagenesis, Control